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5-Azacytidine



Catalog Number : 3206727

Description

5-Azacytidine is a DNA methyltransferase inhibitor that induces the demethylation and reactivation of silenced genes. It is an epigenetic modifier and chemical analogue of cytidine, a DNA and RNA nucleotide. 5-Azacytidine is reported to inhibit the proliferation of several cancer cell lines by reducing hypermethylation and is useful for stem cell research as it can enhance the differentiation of embryonic stem cells into cardiomyocytes and reset the epigenetic memory of mouse IPS cells. A recent study reported that 5-Azacytidine in conjunction with PDGF-AB can induce the conversion of somatic cells into tissue-regenerative multipotent stem cells.
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Additional Information

Applications
FA
Synonyms:
Ladakamycin, NSC 102816, Vidaza
Formulation:
Crystalline solid
Chemical Name:
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Molecular Formula:

C8H12N4O5

Molecular Weight:
244.2
CAS Number
320-67-2
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Chandrakanthan, V., Yeola, A., Kwan, J. C., Oliver, R. A., Qiao, Q., Kang, Y. C., ... & Villanueva, J. E. (2016). PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.Proceedings of the National Academy of Sciences, 201518244.

Christman, J. K. (2002). 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene21(35), 5483-5495.

Wakitani, S., Saito, T., & Caplan, A. I. (1995). Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5‐azacytidine. Muscle & nerve18(12), 1417-1426.

Jones, P. A. (1985). Altering gene expression with 5-azacytidine. Cell40(3), 485-486.


Availability: In stock

Size Price Qty
50mg
$20.00
250mg
$75.00