Zidovudine

Grouped product items
Size	Price	Qty
100mg	$90.00
1g	$190.00

Catalog Number : 3058716

description

Zidovudine (Azidothymidine or AZT) is a thymidine analogue that selectively inhibits HIV’s reverse transcriptase. It is reported to be inhibit DNA polymerase used by human cells in high doses. Zidovudine can also be used to decrease CRISPR-mediated homology-directed repair efficiency.

Additional Information

Applications:	FA
Synonyms:	Azidothymidine, AZT, 3' Azido 2',3' Dideoxythymidine, Retrovir, Zidovudinum
Formulation:	Crystalline solid
Chemical Name:	1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Molecular Formula:	C₁₀H₁₃N₅O₄
Molecular Weight:	267.3
CAS Number	30516-87-1
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Blum, M. R., Liao, S. H., Good, S. S., & De Miranda, P. (1988). Pharmacokinetics and bioavailability of zidovudine in humans. The American journal of medicine, 85(2A), 189-194. Yu, C., Liu, Y., Ma, T., Liu, K., Xu, S., Zhang, Y., ... & Qi, L. S. (2015). Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell stem cell, 16(2), 142-147. de la Fuente-Núñez, C., & Lu, T. K. (2017). CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects. Integrative Biology. Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., ... & Jackson, G. G. (1987). The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. New England Journal of Medicine, 317(4), 185-191.