(Z)-4-Hydroxytamoxifen
Catalog Number : 6800637
description
Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. (Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite with increased potency and a 100x higher affinity for the estrogen receptors. It is also reported to inhibit lipid peroxidation and can be used to activate intein-linked or estrogen receptor ERT2 domain fused Cas9 to reduce off target effects in CRISPR-mediated gene editing.
Additional Information
Applications:
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FA
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Synonyms:
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4OH-tamoxifen, (Z)-4-hydroxy Tamoxifen, Afimoxifene, OHTAM
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
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Molecular Formula:
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C26H29NO2 |
Molecular Weight: |
387.5
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CAS Number
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68047-06-3
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Smith, C. L., Nawaz, Z., & O’Malley, B. W. (1997). Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Molecular endocrinology, 11(6), 657-666. Coward, P., Lee, D., Hull, M. V., & Lehmann, J. M. (2001). 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ.Proceedings of the National Academy of Sciences, 98(15), 8880-8884. Vartak, S. V., & Raghavan, S. C. (2015). Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing. FEBS journal, 282(22), 4289-4294. |