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Y-27632 Dihydrochloride



Catalog Number : 1293823

Description

Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).
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Additional Information

Applications:
FA
Synonyms:
Y 27632, N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide, trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Formulation:
Crystalline solid
Chemical Name:
4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
Molecular Formula:

C14H21N3O2HCl

Molecular Weight:
320.3
CAS Number
129830-38-2
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000). Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Molecular pharmacology57(5), 976-983.

Fu, X., Gong, M. C., Jia, T., Somlyo, A. V., & Somlyo, A. P. (1998). The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPγS-, and phorbol ester-induced Ca 2+-sensitization of smooth muscle. FEBS letters,440(1), 183-187.

Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., ... & Sasai, Y. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature biotechnology25(6), 681-686.


Availability: In stock

Size Price Qty
1mg
$50.00
10mg
$175.00
50mg
$600.00