Y-27632 Dihydrochloride
Catalog Number : 1293823
description
Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).
Additional Information
Applications: | FA |
Synonyms: | Y 27632, N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide, trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
Formulation: | Crystalline solid |
Chemical Name: | 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride |
Molecular Formula: | C14H21N3O2HCl |
Molecular Weight: | 320.3 |
CAS Number | 129830-38-2 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000). Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Molecular pharmacology, 57(5), 976-983. Fu, X., Gong, M. C., Jia, T., Somlyo, A. V., & Somlyo, A. P. (1998). The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPγS-, and phorbol ester-induced Ca 2+-sensitization of smooth muscle. FEBS letters,440(1), 183-187. Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., ... & Sasai, Y. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature biotechnology, 25(6), 681-686. |