U0126
description
Additional Information
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Applications:
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FA
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Synonyms:
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U-0126, UO-126
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Formulation:
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Crystalline solid
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Chemical Name:
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(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
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Molecular Formula:
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C18H16N6S2 |
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Molecular Weight: |
380.5
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CAS Number
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109511-58-2
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Duncia, J. V., Santella, J. B., Higley, C. A., Pitts, W. J., Wityak, J., Frietze, W. E., ... & Teleha, C. A. (1998). MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorganic & medicinal chemistry letters, 8(20), 2839-2844. Satoh, T., Nakatsuka, D., Watanabe, Y., Nagata, I., Kikuchi, H., & Namura, S. (2000). Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neuroscience letters, 288(2), 163-166. Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K. I., Kitaura, H., ... & Nakayama, K. (2002). U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells.Journal of Biological Chemistry, 277(49), 47366-47372. Ge, X., Fu, Y. M., & Meadows, G. G. (2002). U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells. Cancer letters, 179(2), 133-140. |