TWS 119

Grouped product items
Size Price Qty
10mg
$145.00
25mg
$320.00
Catalog Number : 6011964

description

TWS 119 is a potent glycogen synthase kinase-3β inhibitor (IC50 =30nM). It is used to induce neuronal differentiation and functions as a WNT pathway activator. TWS 119 is also reported to promote the expression of CD62L in NK cells and inhibit the proliferation and induce apoptosis of alveolar rhabdomyosarcoma (ARMS) cells.

Additional Information

Applications:
FA
Synonyms:
TWS119; TWS-119; GSK-3beta Inhibitor XII, Neurogenesis Inducer
Formulation:
Crystalline solid
Chemical Name:
3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Molecular Formula:

C18H14N4O2

Molecular Weight:
318.3
CAS Number
601514-19-6
Purity:
≥90%
Storage Conditions:
Product should be kept at -20°C.
References:

Zeng, F. Y., Dong, H., Cui, J., Liu, L., & Chen, T. (2010). Glycogen synthase kinase 3 regulates PAX3–FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochemical and biophysical research communications391(1), 1049-1055.

Doble, B. W., & Woodgett, J. R. (2009). Exploring pluripotency with chemical genetics. Cell Stem Cell4(2), 98-100.

Ding, S., Wu, T. Y., Brinker, A., Peters, E. C., Hur, W., Gray, N. S., & Schultz, P. G. (2003). Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences100(13), 7632-7637.

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