Zebularine

Grouped product items
SizePrice Qty
1mg
$25.00
10mg
$110.00
Catalog Number : 3691061

description

Zebularine is a nucleoside analog of cytidine that inhibits DNA methylation and tumor growth. It functions by forming a complex with DNA methyltransferases and stabilizing their binding to DNA. Zebularine also inhibits cytidine deaminase and is reported to induce the differentiation of mesenchymal stem cells into cardiomyocytes.
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Additional Information

Applications:
FA
Synonyms:
IN1416, CHEMBL286977, pyrimidin-2-one ribonucleoside, NSC 309132
Formulation:
Crystalline solid
Chemical Name:
1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Molecular Formula:

C9H12N2O5

Molecular Weight:
228.2
CAS Number
3690-10-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Cheng, J. C., Matsen, C. B., Gonzales, F. A., Ye, W., Greer, S., Marquez, V. E., ... & Selker, E. U. (2003). Inhibition of DNA methylation and reactivation of silenced genes by zebularine. Journal of the National Cancer Institute95(5), 399-409.

Zhou, L., Cheng, X., Connolly, B. A., Dickman, M. J., Hurd, P. J., & Hornby, D. P. (2002). Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. Journal of molecular biology321(4), 591-599.

Addison, M. K., Coley, L. W., Gentry, G. T., Godke, R. A., & Bondioli, K. R. (2011). 209 epigenetic modification with zebularine and valproic acid and expression of pluripotency genes in bovine adipose stem cells. Reproduction, Fertility and Development24(1), 216-217.

Naeem, N., Haneef, K., Kabir, N., Iqbal, H., Jamall, S., & Salim, A. (2013). DNA Methylation Inhibitors, 5‐azacytidine and Zebularine Potentiate the Transdifferentiation of Rat Bone Marrow Mesenchymal Stem Cells into Cardiomyocytes. Cardiovascular therapeutics31(4), 201-209.

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