Zebularine

Grouped product items
Size	Price	Qty
1mg	$25.00
10mg	$125.00

Catalog Number : 3691061

description

Zebularine is a nucleoside analog of cytidine that inhibits DNA methylation and tumor growth. It functions by forming a complex with DNA methyltransferases and stabilizing their binding to DNA. Zebularine also inhibits cytidine deaminase and is reported to induce the differentiation of mesenchymal stem cells into cardiomyocytes.

Additional Information

Applications:	FA
Synonyms:	IN1416, CHEMBL286977, pyrimidin-2-one ribonucleoside, NSC 309132
Formulation:	Crystalline solid
Chemical Name:	1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Molecular Formula:	C₉H₁₂N₂O₅
Molecular Weight:	228.2
CAS Number	3690-10-6
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Cheng, J. C., Matsen, C. B., Gonzales, F. A., Ye, W., Greer, S., Marquez, V. E., ... & Selker, E. U. (2003). Inhibition of DNA methylation and reactivation of silenced genes by zebularine. Journal of the National Cancer Institute, 95(5), 399-409. Zhou, L., Cheng, X., Connolly, B. A., Dickman, M. J., Hurd, P. J., & Hornby, D. P. (2002). Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. Journal of molecular biology, 321(4), 591-599. Addison, M. K., Coley, L. W., Gentry, G. T., Godke, R. A., & Bondioli, K. R. (2011). 209 epigenetic modification with zebularine and valproic acid and expression of pluripotency genes in bovine adipose stem cells. Reproduction, Fertility and Development, 24(1), 216-217. Naeem, N., Haneef, K., Kabir, N., Iqbal, H., Jamall, S., & Salim, A. (2013). DNA Methylation Inhibitors, 5‐azacytidine and Zebularine Potentiate the Transdifferentiation of Rat Bone Marrow Mesenchymal Stem Cells into Cardiomyocytes. Cardiovascular therapeutics, 31(4), 201-209.