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(Z)-4-Hydroxytamoxifen



Catalog Number : 6800637

Description

Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. (Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite with increased potency and a 100x higher affinity for the estrogen receptors. It is also reported to inhibit lipid peroxidation and can be used to activate intein-linked or estrogen receptor ERT2 domain fused Cas9 to reduce off target effects in CRISPR-mediated gene editing.
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Additional Information

Applications:
FA
Synonyms:
4OH-tamoxifen, (Z)-4-hydroxy Tamoxifen, Afimoxifene, OHTAM
Formulation:
Crystalline solid
Chemical Name:
4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
Molecular Formula:

C26H29NO2

Molecular Weight:
387.5
CAS Number
68047-06-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Smith, C. L., Nawaz, Z., & O’Malley, B. W. (1997). Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Molecular endocrinology11(6), 657-666.

Coward, P., Lee, D., Hull, M. V., & Lehmann, J. M. (2001). 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ.Proceedings of the National Academy of Sciences98(15), 8880-8884.

Vartak, S. V., & Raghavan, S. C. (2015). Inhibition of nonhomologous end joining to increase the specificity of CRISPR/Cas9 genome editing. FEBS journal282(22), 4289-4294.


Availability: In stock

Size Price Qty
5mg
$120.00
25mg
$360.00