TWS 119

Grouped product items
SizePrice Qty
10mg
$130.00
25mg
$280.00
Catalog Number : 6011964

description

TWS 119 is a potent glycogen synthase kinase-3β inhibitor (IC50 =30nM). It is used to induce neuronal differentiation and functions as a WNT pathway activator. TWS 119 is also reported to promote the expression of CD62L in NK cells and inhibit the proliferation and induce apoptosis of alveolar rhabdomyosarcoma (ARMS) cells.
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Additional Information

Applications:
FA
Synonyms:
TWS119; TWS-119; GSK-3beta Inhibitor XII, Neurogenesis Inducer
Formulation:
Crystalline solid
Chemical Name:
3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Molecular Formula:

C18H14N4O2

Molecular Weight:
318.3
CAS Number
601514-19-6
Purity:
≥90%
Storage Conditions:
Product should be kept at -20°C.
References:

Zeng, F. Y., Dong, H., Cui, J., Liu, L., & Chen, T. (2010). Glycogen synthase kinase 3 regulates PAX3–FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells. Biochemical and biophysical research communications391(1), 1049-1055.

Doble, B. W., & Woodgett, J. R. (2009). Exploring pluripotency with chemical genetics. Cell Stem Cell4(2), 98-100.

Ding, S., Wu, T. Y., Brinker, A., Peters, E. C., Hur, W., Gray, N. S., & Schultz, P. G. (2003). Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences100(13), 7632-7637.

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