Kenpaullone

Grouped product items
SizePrice Qty
1mg
$45.00
10mg
$165.00
Catalog Number : 1422097

description

Kenpaullone is a potent ATP-competitive inhibitor of glycogen synthase kinase 3Beta and CDK1/Cyclin B. It also inhibits CDk2/Cyclin A, CDk5/p25, and CDk2/Cyclin E. Kenpaullone is reported to enhance the chemical reprogramming of induced pluripotent stem cells from somatic cells.
product image

Additional Information

Applications:
FA
Synonyms:
1-azakenpaullone, NSC-664704
Formulation:
Crystalline solid
Chemical Name:
9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Molecular Formula:

C16H11BrN2O

Molecular Weight:
327.2
CAS Number
142273-20-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Brault, L., Migianu, E., Néguesque, A., Battaglia, E., Bagrel, D., & Kirsch, G. (2005). New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells. European journal of medicinal chemistry,40(8), 757-763.

Phiel, C. J., Wilson, C. A., Lee, V. M. Y., & Klein, P. S. (2003). GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature,423(6938), 435-439.

Schultz, C., Link, A., Leost, M., Zaharevitz, D. W., Gussio, R., Sausville, E. A., ... & Kunick, C. (1999). Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. Journal of medicinal chemistry42(15), 2909-2919.

© BioGems International, Inc. All rights reserved.