Kenpaullone
Catalog Number : 1422097
description
Kenpaullone is a potent ATP-competitive inhibitor of glycogen synthase kinase 3Beta and CDK1/Cyclin B. It also inhibits CDk2/Cyclin A, CDk5/p25, and CDk2/Cyclin E. Kenpaullone is reported to enhance the chemical reprogramming of induced pluripotent stem cells from somatic cells.
Additional Information
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Applications:
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FA
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Synonyms:
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1-azakenpaullone, NSC-664704
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Formulation:
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Crystalline solid
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Chemical Name:
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9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
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Molecular Formula:
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C16H11BrN2O |
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Molecular Weight: |
327.2
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CAS Number
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142273-20-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Brault, L., Migianu, E., Néguesque, A., Battaglia, E., Bagrel, D., & Kirsch, G. (2005). New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells. European journal of medicinal chemistry,40(8), 757-763. Phiel, C. J., Wilson, C. A., Lee, V. M. Y., & Klein, P. S. (2003). GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature,423(6938), 435-439. Schultz, C., Link, A., Leost, M., Zaharevitz, D. W., Gussio, R., Sausville, E. A., ... & Kunick, C. (1999). Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. Journal of medicinal chemistry, 42(15), 2909-2919. |