IWP-3

Grouped product items
Size Price Qty
1mg
$35.00
10mg
$200.00
Catalog Number : 6876006

description

IWP-3 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.

Additional Information

Applications:
FA
Synonyms:
Inhibitor of Wnt Production-3
Formulation:
Crystalline solid
Chemical Name:
2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N- (6-methyl-2-benzothiazolyl)-acetamide
Molecular Formula:

C22H17FN4O2S3

Molecular Weight:
484.6
CAS Number
687561-60-0
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology5(2), 100-107.

Willems, E., Spiering, S., Davidovics, H., Lanier, M., Xia, Z., Dawson, M., ... & Mercola, M. (2011). Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell–derived mesoderm.Circulation research109(4), 360-364.

Lanier, M., Schade, D., Willems, E., Tsuda, M., Spiering, S., Kalisiak, J., ... & Cashman, J. R. (2012). Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure–activity relationship study based on inhibitors for the Wnt response. Journal of medicinal chemistry55(2), 697-708.

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