IWP-2

Grouped product items
SizePrice Qty
1mg
$30.00
10mg
$155.00
Catalog Number : 6866167

description

IWP-2 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.
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Additional Information

Applications:
FA
Synonyms:
CHEMBL1257064, F0579-0037
Formulation:
Crystalline solid
Chemical Name:
N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
Molecular Formula:

C22H18N4O2S3

Molecular Weight:
466.6
CAS Number
686770-61-6
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology5(2), 100-107.

Loh, Y. N., Hedditch, E. L., Baker, L. A., Jary, E., Ward, R. L., & Ford, C. E. (2013). The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC cancer13(1), 174.

Mo, M. L., Li, M. R., Chen, Z., Liu, X. W., Sheng, Q., & Zhou, H. M. (2013). Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncology letters,5(5), 1719-1723.

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