IQ-1

Grouped product items
SizePrice Qty
10mg
$160.00
50mg
$705.00
Catalog Number : 3316280

description

IQ-1 is a selective inhibitor of Beta-catenin/p300 signaling by binding to protein phosphatase 2. It is used to maintain embryonic cell pluripotency in Wnt3a-treated cells and prevent spontaneous differentiation. It is also reported to upregulate the expression of Sox2 and Oct4 transcription factors.
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Additional Information

Applications:
FA
Synonyms:
ST50223451, MLS000559249, AC1NY3UK, CHEMBL3193709
Formulation:
Crystalline solid
Chemical Name:
(2E)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
Molecular Formula:

C21H22N4O2

Molecular Weight:
362.4
CAS Number
331001-62-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

cMiyabayashi, T., Teo, J. L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007). Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proceedings of the National Academy of Sciences104(13), 5668-5673.

Chase, L. G., & Firpo, M. T. (2007). Development of serum-free culture systems for human embryonic stem cells. Current opinion in chemical biology,11(4), 367-372.

Miki, T., Yasuda, S. Y., & Kahn, M. (2011). Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Reviews and Reports7(4), 836-846.

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