IQ-1
Catalog Number : 3316280
description
IQ-1 is a selective inhibitor of Beta-catenin/p300 signaling by binding to protein phosphatase 2. It is used to maintain embryonic cell pluripotency in Wnt3a-treated cells and prevent spontaneous differentiation. It is also reported to upregulate the expression of Sox2 and Oct4 transcription factors.
Additional Information
Applications: | FA |
Synonyms: | ST50223451, MLS000559249, AC1NY3UK, CHEMBL3193709 |
Formulation: | Crystalline solid |
Chemical Name: | (2E)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide |
Molecular Formula: | C21H22N4O2 |
Molecular Weight: | 362.4 |
CAS Number | 331001-62-8 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | cMiyabayashi, T., Teo, J. L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007). Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proceedings of the National Academy of Sciences, 104(13), 5668-5673. Chase, L. G., & Firpo, M. T. (2007). Development of serum-free culture systems for human embryonic stem cells. Current opinion in chemical biology,11(4), 367-372. Miki, T., Yasuda, S. Y., & Kahn, M. (2011). Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Reviews and Reports, 7(4), 836-846. |