endo-IWR-1
Catalog Number : 1128234
description
Endo-IWR-1 is a Wnt pathway inhibitor that stabilizes the axis inhibition protein 2 (AXIN2) or conductin. It is reported to maintain pluripotency of human embryonic stem cells when used with CHIR99021 and promote Beta-catenin phosphorylation.
Additional Information
|
Applications:
|
FA
|
|
Synonyms:
|
IWR-1-endo, IWR-1, IWR1-endo
|
|
Formulation:
|
Crystalline solid
|
|
Chemical Name:
|
4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
|
|
Molecular Formula:
|
C25H19N3O3 |
|
Molecular Weight: |
409.4
|
|
CAS Number
|
1127442-82-3
|
|
Purity:
|
≥98%
|
|
Storage Conditions:
|
Product should be kept at -20°C.
|
|
References:
|
Huang, S. M. A., Mishina, Y. M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G. A., ... & Cong, F. (2009). Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature, 461(7264), 614-620. Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Bao, R., Christova, T., Song, S., Angers, S., Yan, X., & Attisano, L. (2012). Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. |