endo-IWR-1

Grouped product items
SizePrice Qty
10mg
$115.00
50mg
$480.00
Catalog Number : 1128234

description

Endo-IWR-1 is a Wnt pathway inhibitor that stabilizes the axis inhibition protein 2 (AXIN2) or conductin. It is reported to maintain pluripotency of human embryonic stem cells when used with CHIR99021 and promote Beta-catenin phosphorylation.
product image

Additional Information

Applications:
FA
Synonyms:
IWR-1-endo, IWR-1, IWR1-endo
Formulation:
Crystalline solid
Chemical Name:
4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Molecular Formula:

C25H19N3O3

Molecular Weight:
409.4
CAS Number
1127442-82-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Huang, S. M. A., Mishina, Y. M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G. A., ... & Cong, F. (2009). Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature461(7264), 614-620.

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology5(2), 100-107.

Bao, R., Christova, T., Song, S., Angers, S., Yan, X., & Attisano, L. (2012). Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

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