BIO

Grouped product items
SizePrice Qty
10mg
$155.00
25mg
$345.00
Catalog Number : 6676296

description

BIO is a cell-permeable selective irreversible inhibitor of glycogen synthase kinase-3 (GSK-3). This inhibitory effect is reported to activate the Wnt signaling pathway and promote self-renewal in human and mouse cells. BIO is also useful in the differentiation of cardiomyocytes from human embryonic cells and Induced pluripotent stem cells as well as cellular reprogramming of mouse cell lines into iPS cells.
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Additional Information

Applications:
FA
Synonyms:
MLS001074886, SCHEMBL15565919, SMR000568408, 6BIO
Formulation:
Crystalline solid
Chemical Name:
(3E)-6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1H-indol-2-one
Molecular Formula:

C16H10BrN3O2

Molecular Weight:
356.2
CAS Number
667463-62-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Meijer, L., Skaltsounis, A. L., Magiatis, P., Polychronopoulos, P., Knockaert, M., Leost, M., ... & Greengard, P. (2003). GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chemistry & biology10(12), 1255-1266.

Tseng, A. S., Engel, F. B., & Keating, M. T. (2006). The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chemistry & biology,13(9), 957-963.

Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., & Brivanlou, A. H. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature medicine10(1), 55-63.

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