Verapamil hydrochloride
Catalog Number : 1521142
description
Verapamil is an L-type calcium channel blocker and an inhibitor of drug efflux pump proteins such as P-glycoprotein that are often over-expressed in certain tumor cell lines. It is reported to exhibit vasodilator effects and increase the supply of blood and oxygen to the heart.
Additional Information
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Applications:
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FA
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Synonyms:
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Verapamil HCl, Manidon, Veroptinstada
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Formulation:
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Crystalline solid
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Chemical Name:
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2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
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Molecular Formula:
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C27H38N2O4 HCL |
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Molecular Weight: |
491.1
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CAS Number
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152-11-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Lee, K. S., & Tsien, R. W. (1983). Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature, 302(5911), 790. Henry, P. D. (1980). Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. The American journal of cardiology, 46(6), 1047-1058. Miller, T. P., Grogan, T. M., Dalton, W. S., Spier, C. M., Scheper, R. J., & Salmon, S. E. (1991). P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. Journal of Clinical Oncology, 9(1), 17-24. |