Valproic acid sodium salt

Grouped product items
Size	Price	Qty
25g	$70.00
100g	$200.00

Catalog Number : 1066656

description

Valproic Acid (VPA) is a histone deacetylase (HDAC) inhibitor with anti-inflammatory, neuroprotective and anticonvulsant properties. It also inhibits the enzymes in gamma-Aminobutyric acid (GABA) metabolism leading to increased levels of GABA and also, to deplete cellular inositol synthesis. VPA is reported to promote the self-renewal and differentiation of hematopoietic progenitor cells and be useful in generating induced pluripotent stem cells, in combination with other small molecules and growth factors.

Additional Information

Applications:	FA
Synonyms:	2-Propylpentanoic Acid, Convulsofin, Depakene, Depakine, Divalproex, Ergenyl
Formulation:	Crystalline solid
Chemical Name:	sodium;2-propylpentanoate
Molecular Formula:	C₈H₁₅O₂Na
Molecular Weight:	166.2
CAS Number	1069-66-5
Purity:	≥95%
Storage Conditions:	Product should be kept at -20°C.
References:	Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001). Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. Journal of Biological Chemistry,276(39), 36734-36741. Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., ... & Heinzel, T. (2001). Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. The EMBO journal, 20(24), 6969-6978. Bug, G., Gül, H., Schwarz, K., Pfeifer, H., Kampfmann, M., Zheng, X., ... & Ruthardt, M. (2005). Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Research, 65(7), 2537-2541. Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., & Melton, D. A. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature biotechnology, 26(7), 795-797.