Tamoxifen
Catalog Number : 1052910
description
Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. It is metabolized in the liver to 4- hydroxytamoxifen (afimoxifene) and N-desmethyl-4-hydroxytamoxifen (endoxifen), which compete with estrogen for binding to the estrogen receptor. Tamoxifen also has neuroprotective properties in female rats and is reported to block certain cancer cell growth.
Additional Information
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Applications:
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FA
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Synonyms:
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Crisafenom, Citofen, Nolvadex, Oncomox, Soltamox
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Formulation:
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Crystalline solid
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Chemical Name:
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2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
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Molecular Formula:
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C26H29NO |
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Molecular Weight: |
371.5
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CAS Number
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10540-29-1
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Fisher, B., Costantino, J. P., Wickerham, D. L., Redmond, C. K., Kavanah, M., Cronin, W. M., ... & Bowel Project Investigators. (1998). Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. Journal of the National Cancer Institute, 90(18), 1371-1388. Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998). The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell, 95(7), 927-937. Kimelberg, H. K., Jin, Y., Charniga, C., & Feustel, P. J. (2003). Neuroprotective activity of tamoxifen in permanent focal ischemia. Journal of neurosurgery,99(1), 138-142. |