Y-27632 Dihydrochloride
Catalog Number : 1293823
description
Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).
Additional Information
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Applications:
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FA
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Synonyms:
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Y 27632, N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide, trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide;dihydrochloride
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Molecular Formula:
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C14H21N3O2HCl |
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Molecular Weight: |
320.3
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CAS Number
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129830-38-2
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000). Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Molecular pharmacology, 57(5), 976-983. Fu, X., Gong, M. C., Jia, T., Somlyo, A. V., & Somlyo, A. P. (1998). The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPγS-, and phorbol ester-induced Ca 2+-sensitization of smooth muscle. FEBS letters,440(1), 183-187. Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., ... & Sasai, Y. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature biotechnology, 25(6), 681-686. |