Prostaglandin D2
Catalog Number : 4150768
description
Prostaglandin D2 is the major prostaglandin produced by mast cells and is the primary prostaglandin in the brain. It causes vasodilation, induces inflammation, and its presence in hair follicles may be partially responsible for male pattern baldness. Prostaglandin D2 is released during asthmatic and allergic reactions.
Additional Information
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Applications:
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FA
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Synonyms:
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11-Dehydroprostaglandin F2alpha, PGD2
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Formulation:
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Crystalline solid
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Chemical Name:
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(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
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Molecular Formula:
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C20H32O5 |
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Molecular Weight: |
352.5
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CAS Number
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41598-07-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Murray, J. J., Tonnel, A. B., Brash, A. R., Roberts, L. J., Gosset, P., Workman, R., ... & Oates, J. A. (1986). Release of prostaglandin D2 into human airways during acute antigen challenge. New England Journal of Medicine, 315(13), 800-804. Monneret, G., Gravel, S., Diamond, M., Rokach, J., & Powell, W. S. (2001). Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood, 98(6), 1942-1948. Garza, L. A., Liu, Y., Yang, Z., Alagesan, B., Lawson, J. A., Norberg, S. M., ... & Cotsarelis, G. (2012). Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Science translational medicine,4(126), 126ra34-126ra34. |