OAC-1
Catalog Number : 3009078
description
OAC-1 activates OCT-4, a transcription factor involved in the self-renewal of undifferentiated stem cells. It is commonly used to enhance the efficiency of reprogramming embryonic fibroblasts. OAC-1 does not seem to effect Wnt-Beta-catenin signaling or the pt3-p21 pathway.
Additional Information
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Applications:
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FA
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Synonyms:
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BAS 00287861, OAC1, AC1LG6VC
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Formulation:
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Crystalline solid
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Chemical Name:
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N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide
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Molecular Formula:
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C14H11N3O |
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Molecular Weight: |
237.3
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CAS Number
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300586-90-7
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Li, W., Tian, E., Chen, Z. X., Sun, G., Ye, P., Yang, S., ... & Shi, Y. (2012). Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences, 109(51), 20853-20858. Huang, X., Cooper, S., & Broxmeyer, H. E. (2014). Activation of OCT4 Enhances Ex Vivo Expansion of Phenotypically Defined and Functionally Engraftable Human Cord Blood Hematopoietic Stem and Progenitor Cells By Regulating HOXB4 Expression. Blood, 124(21), 4332-4332. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. cell, 131(5), 861-872. |