LDN193189

Grouped product items
SizePrice Qty
1mg
$40.00
10mg
$235.00
Catalog Number : 1062443

description

LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification.
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Additional Information

Applications:
FA
Synonyms:
DM-3189
Formulation:
Crystalline solid
Chemical Name:
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolone
Molecular Formula:

C25H22N6

Molecular Weight:
406.5
CAS Number
1062368-24-4
Purity:
≥95%
Storage Conditions:
Product should be kept at-20°C.
References:

Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807

Kreitzer, F. R., Salomonis, N., Sheehan, A., Huang, M., Park, J. S., Spindler, M. J., ... & Conklin, B. R. (2013). A robust method to derive functional neural crest cells from human pluripotent stem cells. American journal of stem cells,2(2), 119.

Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., ... & Paul, B. Y. (2012). Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 32(3), 613-622.

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