Wnt-C59

Grouped product items
Size	Price	Qty
10mg	$180.00
50mg	$745.00

Catalog Number : 1248913

description

Wnt-C59 is a highly potent Porcupine (PORCN) inhibitor that prevents Wnt-3a palmitoylation, secretion and activation (IC50=74pM). It is reported to inhibit cancer cell proliferation in cancer cell lines depended on Wnt activity. Together with CHIR 99021, Wnt-C59 can be used to induce cardiomyocyte differentiation from human induced pluripotent stem cells (iPSCs).

Additional Information

Applications:	FA
Synonyms:	WNTC59
Formulation:	Crystalline solid
Chemical Name:	2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
Molecular Formula:	C₂₅H₂₁N₃O
Molecular Weight:	379.5
CAS Number	1243243-89-1
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Cheng, Y., Phoon, Y. P., Jin, X., Chong, S. Y. S., Ip, J. C. Y., Wong, B. W. Y., & Lung, M. L. (2015). Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget, 6(16), 14428. Proffitt, K. D., Madan, B., Ke, Z., Pendharkar, V., Ding, L., Lee, M. A., ... & Virshup, D. M. (2013). Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer research, 73(2), 502-507. Kadari, A., Mekala, S., Wagner, N., Malan, D., Köth, J., Doll, K., ... & Sasse, P. (2015). Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling. Stem Cell Reviews and Reports, 11(4), 560-569.