U0126

Grouped product items
Size Price Qty
5mg
$145.00
25mg
$560.00
Catalog Number : 1095821

description

U0126 is a highly selective inhibitor of MEK1 (IC50 of 72nM) and MEK2 (IC50 of 58nM) that antagonizes AP-1 transcriptional activity. U0216 helps maintain human pluripotent stem cells in the undifferentiated state. It is also reported to sensitize cells to anoikis, as upon treatment with U0126 cells deprived of anchorage enter apoptosis.

Additional Information

Applications:
FA
Synonyms:
U-0126, UO-126
Formulation:
Crystalline solid
Chemical Name:
(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
Molecular Formula:

C18H16N6S2

Molecular Weight:
380.5
CAS Number
109511-58-2
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Duncia, J. V., Santella, J. B., Higley, C. A., Pitts, W. J., Wityak, J., Frietze, W. E., ... & Teleha, C. A. (1998). MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorganic & medicinal chemistry letters8(20), 2839-2844.

Satoh, T., Nakatsuka, D., Watanabe, Y., Nagata, I., Kikuchi, H., & Namura, S. (2000). Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neuroscience letters288(2), 163-166.

Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K. I., Kitaura, H., ... & Nakayama, K. (2002). U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells.Journal of Biological Chemistry277(49), 47366-47372.

Ge, X., Fu, Y. M., & Meadows, G. G. (2002). U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells. Cancer letters179(2), 133-140.

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