Tranylcypromine hydrochloride
Catalog Number : 1984764
description
Tranylcypromine hydrochloride is a cell-permeable inhibitor of histone demethylzation. It is reported to be an irreversible inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1. It is also useful in chemically reprogramming murine fibroblasts to induced pluripotent stem cells.
Additional Information
Applications:
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FA
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Synonyms:
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Parnate, (1R,2S)-rel-2-phenylcyclopropanamine monohydrochloride, Tranylcypromine hydrochloride, 2-PCPA
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Formulation:
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Crystalline solid
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Chemical Name:
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trans-2-Phenylcyclopropylamine hydrochloride
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Molecular Formula:
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C9H11N HCl |
Molecular Weight: |
169.7
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CAS Number
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1986-47-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., ... & Deng, H. (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science, 341(6146), 651-654. Zhou, H., Li, W., Zhu, S., Joo, J. Y., Do, J. T., Xiong, W., ... & Ding, S. (2010). Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. Journal of Biological Chemistry, 285(39), 29676-29680. Schmidt, D. M., & McCafferty, D. G. (2007). trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.Biochemistry, 46(14), 4408-4416. |