SU5416

Grouped product items
SizePrice Qty
10mg
$110.00
50mg
$470.00
Catalog Number : 2044690

description

SU5416 is a potent and selective inhibitor of the Flk-1/KDR vascular endothelial growth factor (VEGF) receptor tyrosine kinase and also inhibits c-kit, RET, and FLT3. It is reported to inhibit tumor vascularization and suppress the growth of multiple tumor types.
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Additional Information

Applications:
FA
Synonyms:
Semaxinib, SU-5416, SU 5416
Formulation:
Crystalline solid
Chemical Name:
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Molecular Formula:

C15H14N2O

Molecular Weight:
238.3
CAS Number
204005-46-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Fong, T. A. T., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., ... & Ullrich, A. (1999). SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer research59(1), 99-106.

Mendel, D. B., Laird, A. D., Smolich, B. D., Blake, R. A., Liang, C., Hannah, A. L., ... & Cherrington, J. M. (2000). Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anti-cancer drug design15(1), 29-41.

Smolich, B. D., Yuen, H. A., West, K. A., Giles, F. J., Albitar, M., & Cherrington, J. M. (2001). The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood97(5), 1413-1421.

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