SU5416
description
Additional Information
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Applications:
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FA
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Synonyms:
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Semaxinib, SU-5416, SU 5416
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Formulation:
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Crystalline solid
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Chemical Name:
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(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
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Molecular Formula:
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C15H14N2O |
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Molecular Weight: |
238.3
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CAS Number
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204005-46-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Fong, T. A. T., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., ... & Ullrich, A. (1999). SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer research, 59(1), 99-106. Mendel, D. B., Laird, A. D., Smolich, B. D., Blake, R. A., Liang, C., Hannah, A. L., ... & Cherrington, J. M. (2000). Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anti-cancer drug design, 15(1), 29-41. Smolich, B. D., Yuen, H. A., West, K. A., Giles, F. J., Albitar, M., & Cherrington, J. M. (2001). The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood, 97(5), 1413-1421. |