SR 95531 Hydrobromide
Catalog Number : 1045090
description
SR 95531 is a selective GABAA receptor antagonist, inhibiting chloride flux across the cell membrane and neuronal hyperpolarization. It is reported to elicit convulsions in mice and rats.
Additional Information
Applications:
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FA
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Synonyms:
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SR-95531, Gabazine bromide
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[6-amino-3-(4-methoxyphenyl)pyridazin-1-ium-1-yl]butanoic acid;bromide
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Molecular Formula:
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C15H17N3O3 HBr |
Molecular Weight: |
368.2
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CAS Number
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104104-50-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Heaulme, M., Chambon, J. P., Leyris, R., Wermuth, C. G., & Biziere, K. (1987). Characterization of the binding of [3H] SR 95531, a GABAA antagonist, to rat brain membranes. Journal of neurochemistry, 48(6), 1677-1686. Hamann, M., Desarmenien, M., Desaulles, E., Bader, M. F., & Feltz, P. (1988). Quantitative evaluation of the properties of a pyridazinyl GABA derivative (SR 95531) as a GABAA competitive antaginist. An electrophysiological approach. Brain research, 442(2), 287-296. Mienville, J. M., & Vicini, S. (1987). A pyridazinyl derivative of gamma-aminobutyric acid (GABA), SR 95531, is a potent antagonist of Cl− channel opening regulated by GABAA receptors. Neuropharmacology, 26(7), 779-783. |