SP 600125

Grouped product items
SizePrice Qty
10mg
$60.00
50mg
$175.00
Catalog Number : 1295666

description

SP 600125 is an anthrone derivative that potently and reversibly inhibits c-Jun N-terminal kinases (JNKs), effecting JNK 1-3. It is reported to prevent apoptosis in many cell lines and inhibit BMP-9 induced osteogenic differentiation of mouse mesenchymal stem cells.
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Additional Information

Applications:
FA
Synonyms:
1,9-Pyrazoloanthrone, SP600125, Pyrazolanthrone, Anthrapyrazolone
Formulation:
Crystalline solid
Chemical Name:
anthra[1,​9-​cd]pyrazol-​6(2H)-​one
Molecular Formula:

C14H8N2O

Molecular Weight:
220.2
CAS Number
129-56-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Xia, H. H. X., He, H., De Wang, J., Gu, Q., Lin, M. C., Zou, B., ... & Wong, B. C. Y. (2006). Induction of apoptosis and cell cycle arrest by a specific c-Jun NH 2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers.Cancer letters241(2), 268-274.

Roy, P. K., Rashid, F., Bragg, J., & Ibdah, J. A. (2008). Role of the JNK signal transduction pathway in inflammatory bowel disease. World journal of gastroenterology: WJG14(2), 200.

Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., ... & Anderson, D. W. (2001). SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proceedings of the National Academy of Sciences,98(24), 13681-13686.

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