SP 600125
Catalog Number : 1295666
description
SP 600125 is an anthrone derivative that potently and reversibly inhibits c-Jun N-terminal kinases (JNKs), effecting JNK 1-3. It is reported to prevent apoptosis in many cell lines and inhibit BMP-9 induced osteogenic differentiation of mouse mesenchymal stem cells.
Additional Information
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Applications:
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FA
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Synonyms:
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1,9-Pyrazoloanthrone, SP600125, Pyrazolanthrone, Anthrapyrazolone
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Formulation:
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Crystalline solid
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Chemical Name:
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anthra[1,9-cd]pyrazol-6(2H)-one
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Molecular Formula:
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C14H8N2O |
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Molecular Weight: |
220.2
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CAS Number
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129-56-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Xia, H. H. X., He, H., De Wang, J., Gu, Q., Lin, M. C., Zou, B., ... & Wong, B. C. Y. (2006). Induction of apoptosis and cell cycle arrest by a specific c-Jun NH 2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers.Cancer letters, 241(2), 268-274. Roy, P. K., Rashid, F., Bragg, J., & Ibdah, J. A. (2008). Role of the JNK signal transduction pathway in inflammatory bowel disease. World journal of gastroenterology: WJG, 14(2), 200. Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., ... & Anderson, D. W. (2001). SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proceedings of the National Academy of Sciences,98(24), 13681-13686. |