SAHA

Grouped product items
SizePrice Qty
250mg
$50.00
1g
$170.00
Catalog Number : 1497894

description

SAHA is a potent reversible pan-histone deacetylase inhibitor, including both class I and class II HDACs. It functions by binding to the active site of histone deacetylases and acting as a chelator of Zinc ions. SAHA is used to halt the growth of transformed cells, induce apoptosis in T cell lymphoma, and arrest cancer cell growth.
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Additional Information

Applications:
FA
Synonyms:
Vorinostat, Zolinza, suberoylanilide hydroxamic acid, Suberanilohydroxamic acid
Formulation:
Crystalline solid
Chemical Name:
N'-hydroxy-N-phenyloctanediamide
Molecular Formula:

C14H20N2O3

Molecular Weight:
264.3
CAS Number
149647-78-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C., ... & Frankel, S. R. (2007). Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood109(1), 31-39.

Marks, P. A., & Breslow, R. (2007). Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nature biotechnology25(1), 84-90.

Shankar, S., Davis, R., Singh, K. P., Kurzrock, R., Ross, D. D., & Srivastava, R. K. (2009). Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice. Molecular cancer therapeutics8(6), 1596-1605.

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