Rolipram
Catalog Number : 6145453
description
Rolipram is a selective Type 4 cyclic nucleotide phosphodiesterases (PDE4) inhibitor, affective isoform A over other isoforms. It is reported to inhibit inflammation and induces neural differentiation of bone marrow-derived mesenchymal stem cells.
Additional Information
Applications:
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FA
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Synonyms:
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ZK 62711, Rolipramum,
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Formulation:
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Crystalline solid
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Chemical Name:
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4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
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Molecular Formula:
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C16H21NO3 |
Molecular Weight: |
275.3
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CAS Number
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61413-54-5
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., ... & Ge, J. (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science, 341(6146), 651-654. Sommer, N., Löschmann, P. A., Northoff, G. H., Weller, M., Steinbrecher, A., Steinbach, J. P., ... & Dichgans, J. (1995). The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nature medicine, 1(3), 244. Semmler, J., Wachtell, H., & Endres, S. (1993). The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells. International journal of immunopharmacology, 15(3), 409-413. |