RG108

Grouped product items
SizePrice Qty
10mg
$105.00
50mg
$435.00
Catalog Number : 4822608

description

RG108 is a non-nucleoside DNA methyltransferase inhibitor by binding and blocking the active site of the methyltransferase enzyme. Unlike nucleoside based inhibitors, it reduces the methylation of DNA without detectable toxicity. RG108 is reported to be used to reactivate epigenetically silenced tumor suppressor genes and enhance the reprogramming efficiency of induced pluripotent stem cells.
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Additional Information

Applications:
FA
Synonyms:
RG-108, RG 108, CHEMBL1564869, NCI401077
Formulation:
Crystalline solid
Chemical Name:
(2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
Molecular Formula:

C19H14N2O4

Molecular Weight:
334.3
CAS Number
48208-26-0
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Schirrmacher, E., Beck, C., Brueckner, B., Schmitges, F., Siedlecki, P., Bartenstein, P., ... & Schirrmacher, R. (2006). Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjugate chemistry,17(2), 261-266.

Asgatay, S., Champion, C., Marloie, G., Drujon, T., Senamaud-Beaufort, C., Ceccaldi, A., ... & Guianvarc’h, D. (2014). Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1. Journal of medicinal chemistry57(2), 421-434.

Shi, Y., Desponts, C., Do, J. T., Hahm, H. S., Schöler, H. R., & Ding, S. (2008). Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell stem cell3(5), 568-574.

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