Remdesivir

Grouped product items
SizePrice Qty
1mg
$410.00
5mg
$1,135.00
Catalog Number : 1803739

description

Remdesivir is a prodrug that metabolizes into its active form GS-441524, which interferes with the action of viral RNA polymerase and degrades viral RNA production. It is reported to exhibit antiviral activity against single stranded RNA viruses such as Ebola, Marburg, Hendra, and coronaviruses. It is currently being researched as a potential treatment for COVID-19.
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Additional Information

Applications:
FA
Synonyms:
GS-5734
Formulation:
Crystalline solid
Chemical Name:
2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
Molecular Formula:

C27H35N6O8P

Molecular Weight:
602.6
CAS Number
1809249-37-3
Purity:
98%
Storage Conditions:
Product should be kept at -20°C.
References:

Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., ... & Xiao, G. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell research30(3), 269-271.

Gordon, C. J., Tchesnokov, E. P., Feng, J. Y., Porter, D. P., & Gotte, M. (2020). The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. Journal of Biological Chemistry, jbc-AC120.

de Wit, E., Feldmann, F., Cronin, J., Jordan, R., Okumura, A., Thomas, T., ... & Feldmann, H. (2020). Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proceedings of the National Academy of Sciences.

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