Remdesivir
Catalog Number : 1803739
description
Remdesivir is a prodrug that metabolizes into its active form GS-441524, which interferes with the action of viral RNA polymerase and degrades viral RNA production. It is reported to exhibit antiviral activity against single stranded RNA viruses such as Ebola, Marburg, Hendra, and coronaviruses. It is currently being researched as a potential treatment for COVID-19.
Additional Information
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Applications:
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FA
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Synonyms:
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GS-5734
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Formulation:
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Crystalline solid
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Chemical Name:
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2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
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Molecular Formula:
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C27H35N6O8P |
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Molecular Weight: |
602.6
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CAS Number
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1809249-37-3
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Purity:
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98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., ... & Xiao, G. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell research, 30(3), 269-271. Gordon, C. J., Tchesnokov, E. P., Feng, J. Y., Porter, D. P., & Gotte, M. (2020). The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. Journal of Biological Chemistry, jbc-AC120. de Wit, E., Feldmann, F., Cronin, J., Jordan, R., Okumura, A., Thomas, T., ... & Feldmann, H. (2020). Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proceedings of the National Academy of Sciences. |