Rapamycin

Grouped product items
SizePrice Qty
1mg
$35.00
10mg
$125.00
Catalog Number : 5318893

description

Rapamycin was first evaluated as an antifungal agent, but is now studied for its potent immunosuppressive and antiproliferative properties. It forms a complex with FKBP12 and directly binds to mTORC1, inhibiting the functions of the mTOR pathway. Rapamycin is reported to block protein synthesis, arrest cell cycle progression, and inhibit IL-2 signal transduction mechanisms.
product image

Additional Information

Applications:
FA
Synonyms:
Sirolimus, Rapamune, AY 22989
Formulation:
Crystalline solid
Chemical Name:
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)­9,10,12,13,14,21,22,23,24,25,26,27,32,33,34, 34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2­[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy­6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclohentriacontine­1,5,11,28,29 (4H,6H,31H)-pentone
Molecular Formula:

C51H79NO13

Molecular Weight:
914.2
CAS Number
53123-88-9
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Nourse, J., Firpo, E., Flanagan, W. M., Coats, S., Polyak, K., Lee, M. H., ... & Roberts, J. M. (1994). lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin.

Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature358(6381), 70-73.

Hidalgo, M., & Rowinsky, E. K. (2000). The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene19(56), 6680-6686.

© BioGems International, Inc. All rights reserved.