PluriSln 1
Catalog Number : 9138826
description
PluriSln 1 a stearoyl-CoA desaturase 1 (SCD1) inhibitor used to selectively eliminate undifferentiated human pluripotent stem cells. It induces apoptosis in hPSCs to the exclusion of differentiated or progenitor cells. It is reported to prevent teratoma formation in immunocompromised mice.
Additional Information
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Applications:
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FA
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Synonyms:
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NSC 14613, 4-Pyridinecarboxylicacid, 2-phenylhydrazide
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Formulation:
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Crystalline solid
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Chemical Name:
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N'-phenylpyridine-4-carbohydrazide
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Molecular Formula:
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C12H11N3O |
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Molecular Weight: |
213.2
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CAS Number
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91396-88-2
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Ben-David, U., Gan, Q. F., Golan-Lev, T., Arora, P., Yanuka, O., Oren, Y. S., ... & Benvenisty, N. (2013). Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.Cell Stem Cell, 12(2), 167-179. Phillips, M. I. (2014). Tumor-free iPS stem cells for heart cells. Cell Cycle,13(10), 1519-1519. Lou, K. J. (2013). Small molecules vs. teratomas. SciBX: Science-Business eXchange, 6(7). |