Pluripotin

Grouped product items
SizePrice Qty
1mg
$50.00
10mg
$250.00
Catalog Number : 8393780

description

Pluripotin is an inhibitor of both RasGAP and ERK1. The inhibition of RasGAP is used to promote self-renewal and the inhibition of ERK1 blocks cell differentiation. Pluripotin can be conbined with leukemia inhibitory factor (LIF) to promote the derivation of embryonic cell lines from refractory strains.
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Additional Information

Applications:
FA
Synonyms:
SC-1, SC1
Formulation:
Crystalline solid
Chemical Name:
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Molecular Formula:

C27H25F3N8O2

Molecular Weight:
550.5
CAS Number
839707-37-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Yang, W., Wei, W., Shi, C., Zhu, J., Ying, W., Shen, Y., ... & Deng, H. (2009). Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells,27(2), 383-389.

Pieters, T., Haenebalcke, L., Hochepied, T., D’Hont, J., Haigh, J. J., Van Roy, F., & van Hengel, J. (2012). Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells. Stem Cell Reviews and Reports,8(3), 768-778.

Duan, H., Wang, Y., Yang, L., Qu, M., Wang, Q., Shi, W., & Zhou, Q. (2012). Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. Experimental eye research100, 52-58.

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