Pifithrin-mu

Grouped product items
SizePrice Qty
10mg
$70.00
25mg
$165.00
Catalog Number : 6493124

description

Pifithrin-mu is a cell-permeable inhibitor of p53, which plays a crucial role in apoptosis, angiogenesis, and genomic stability. It is reported to be capable of increasing the efficiency of inducing pluripotent stem cells and reduce radiation induced cell death. Unlike the alpha version, Pifithrin-mu inhibits the p53-mitochornidral pathway without affecting the transcriptional functions of p53.
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Additional Information

Applications:
FA
Synonyms:
pifithrin-mu, 2-phenylacetylenesulfonamide, NSC 303580
Formulation:
Crystalline solid
Chemical Name:
2-phenylethynesulfonamide
Molecular Formula:

C8H7NO2S

Molecular Weight:
181.2
CAS Number
64984-31-2
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Strom, E., Sathe, S., Komarov, P. G., Chernova, O. B., Pavlovska, I., Shyshynova, I., ... & Gudkov, A. V. (2006). Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature chemical biology2(9), 474-479.

Leu, J. J., Pimkina, J., Pandey, P., Murphy, M. E., & George, D. L. (2011). HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Molecular Cancer Research9(7), 936-947.

Sekihara, K., Harashima, N., Tamaki, Y., Hieda, Y., Uchida, N., Inomata, T., & Harada, M. (2013, September). Antitumor effect induced by combination of radiation with a novel HSP70 inhibitor pifithrin-mu on human prostate cancer. InEUROPEAN JOURNAL OF CANCER (Vol. 49, pp. S232-S233). THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND: ELSEVIER SCI LTD.

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