PD 98059

Grouped product items
Size	Price	Qty
10mg	$80.00
50mg	$310.00

Catalog Number : 1672186

description

PD 98059 is a selective non-competitive inhibitor of the activation of mitogen-activated protein kinase kinase (MKK) by binding to the molecule’s inactivated form. It is reported to enhance the self-renewal of embryonic stem cells and block the osteogenic differentiation of human mesenchymal stem cells.

Additional Information

Applications:	FA
Synonyms:	PD98059, PD-98059, 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Formulation:	Crystalline solid
Chemical Name:	2-(2-amino-3-methoxyphenyl)chromen-4-one
Molecular Formula:	C₁₆H₁₃NO₃
Molecular Weight:	267.3
CAS Number	167869-21-8
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Börsch-Haubold, A. G., Pasquet, S., & Watson, S. P. (1998). Direct inhibition of cyclooxygenase-1 and-2 by the kinase inhibitors SB 203580 and PD 98059 SB 203580 also inhibits thromboxane synthase. Journal of Biological Chemistry, 273(44), 28766-28772. Scheid, M. P., Schubert, K. M., & Duronio, V. (1999). Regulation of Bad phosphorylation and association with Bcl-xL by the MAPK/Erk kinase. Journal of Biological Chemistry, 274(43), 31108-31113. Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K. I., Kitaura, H., ... & Nakayama, K. (2002). U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells. Journal of Biological Chemistry, 277(49), 47366-47372. Reiners, J. J., Lee, J. Y., Clift, R. E., Dudley, D. T., & Myrand, S. P. (1998). PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Molecular pharmacology,53(3), 438-445.