PD 173074

Grouped product items
SizePrice Qty
10mg
$110.00
25mg
$220.00
Catalog Number : 2191178

description

PD 173074 is a potent and selective inhibitor of fibroblast growth factors, FGFR1 and FGFR3. It is reported to suppress the differentiation of mouse embryonic cells and promote the survival of human embryonic cells. PD 173074 potently and selectively antagonizes the neurotrophic and neurotropic actions of FGF-2 and displays anti-cancer properties.
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Additional Information

Applications:
FA
Synonyms:
PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor
Formulation:
Crystalline solid
Chemical Name:
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
Molecular Formula:

C28H41N7O3

Molecular Weight:
523.7
CAS Number
219580-11-7
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Skaper, S. D., Kee, W. J., Facci, L., Macdonald, G., Doherty, P., & Walsh, F. S. (2000). The FGFR1 Inhibitor PD 173074 Selectively and Potently Antagonizes FGF‐2 Neurotrophic and Neurotropic Effects. Journal of neurochemistry75(4), 1520-1527.

Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., ... & Hubbard, S. R. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. The EMBO journal17(20), 5896-5904.

Dimitroff, C. J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., ... & Bernacki, R. J. (1999). Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Investigational new drugs17(2), 121-135.

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