PD 173074
description
Additional Information
Applications:
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FA
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Synonyms:
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PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor
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Formulation:
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Crystalline solid
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Chemical Name:
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1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
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Molecular Formula:
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C28H41N7O3 |
Molecular Weight: |
523.7
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CAS Number
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219580-11-7
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Skaper, S. D., Kee, W. J., Facci, L., Macdonald, G., Doherty, P., & Walsh, F. S. (2000). The FGFR1 Inhibitor PD 173074 Selectively and Potently Antagonizes FGF‐2 Neurotrophic and Neurotropic Effects. Journal of neurochemistry, 75(4), 1520-1527. Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., ... & Hubbard, S. R. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. The EMBO journal, 17(20), 5896-5904. Dimitroff, C. J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., ... & Bernacki, R. J. (1999). Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Investigational new drugs, 17(2), 121-135. |