PD 0325901

Grouped product items
SizePrice Qty
10mg
$110.00
25mg
$220.00
Catalog Number : 3911091

description

PD 0325901 is a potent and selective MEK1 and MEK2 inhibitor. It is reported to inhibit cell proliferation and arrest cell cycle at the G0/G1 phase of thyroid cancer cells. PD 0325901 can be used with CHIR99021 to reprogram somatic cells into iPS cells and promote cell self-renewal. Studies have shown that in comparison to the CI-1040 MEK inhibitor that PD 0325901 has a greater potency of inhibition, longer duration, greater solubility, improved bioavailability, and increased metabolic stability.
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Additional Information

Applications:
FA
Synonyms:
PD-0325901, ZINC03938683, NCGC00189075-01, (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
Formulation:
Crystalline solid
Chemical Name:
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
Molecular Formula:

C16H14F3IN2O4

Molecular Weight:
482.2
CAS Number
391210-10-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Sebolt-Leopold, J. S., Merriman, R., Omer, C., Tecle, H., Bridges, A., Klohs, W., ... & Leopold, W. R. (2004). The biological profile of PD 0325901: A second generation analog of CI-1040 with improved pharmaceutical potential. Cancer Research64(7 Supplement), 925-925.

Haura, E. B., Ricart, A. D., Larson, T. G., Stella, P. J., Bazhenova, L., Miller, V. A., ... & Gadgeel, S. M. (2010). A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non–small cell lung cancer. Clinical Cancer Research16(8), 2450-2457.

Leyton, J., Smith, G., Lees, M., Perumal, M., Aigbirhio, F. I., Golovko, O., ... & Aboagye, E. O. (2008). Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. Molecular cancer therapeutics7(9), 3112-3121.

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