NU 7441

Grouped product items
SizePrice Qty
10mg
$125.00
25mg
$275.00
Catalog Number : 5039598

description

NU 7441 is a selective and potent DNA-PK inhibitor (IC50 14nM) and P13K inhibitor (IC50 5uM). It is reported enhance the cytotoxic effects of radiation in cancer cell lines and potentiate the effects of etoposide and doxorubicin. NU 7441 is also reported to enhance the efficiency of CRISPR-Cas9 mediated homology-directed repair (HDR) 2 to 4 fold and decrease nonhomologous end-joining (NHEJ) frequency by 2 fold.
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Additional Information

Applications:
FA
Synonyms:
KU57788, KU 57788, NU-7441, NU7441
Formulation:
Crystalline solid
Chemical Name:
8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
Molecular Formula:

C25H19NO3S

Molecular Weight:
413.5
CAS Number
503468-95-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Robert, F., Barbeau, M., Éthier, S., Dostie, J., & Pelletier, J. (2015). Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome medicine7(1), 93.

Spagnolo, L., Barbeau, J., Curtin, N. J., Morris, E. P., & Pearl, L. H. (2012). Visualization of a DNA-PK/PARP1 complex. Nucleic acids research40(9), 4168-4177.

Zhao, Y., Thomas, H. D., Batey, M. A., Cowell, I. G., Richardson, C. J., Griffin, R. J., ... & Curtin, N. J. (2006). Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer research66(10), 5354-5362.

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