Nocodazole
Catalog Number : 3141890
description
Nocodazole is an antineoplastic microtubule polymerization inhibitor. It is frequently used to synchronize cell cycling and arrest cells with a G2- or M- phase DNA content. It is reported to enhance homology-directed repair (HDR) efficiency and increase Cas9-mediated editing frequencies.
Additional Information
Applications:
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FA
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Synonyms:
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Nocodazolum, ChEMBL9514, Oncodazole
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Formulation:
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Crystalline solid
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Chemical Name:
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methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
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Molecular Formula:
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C14H11N3O3S |
Molecular Weight: |
301.3
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CAS Number
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31430-18-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Vasquez, R. J., Howell, B., Yvon, A. M., Wadsworth, P., & Cassimeris, L. (1997). Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Molecular biology of the cell, 8(6), 973-985. Yang, D., Scavuzzo, M. A., Chmielowiec, J., Sharp, R., Bajic, A., & Borowiak, M. (2016). Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases. Scientific reports, 6. Lin, S., Staahl, B. T., Alla, R. K., & Doudna, J. A. (2014). Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife, 3, e04766. |