Nelfinavir mesylate
Catalog Number : 1596589
description
Nelfinavir is a potent competitive inhibitor of the HIV-1 protease. It is reported that it can also inhibit the growth of various cell types and trigger apoptosis.
Additional Information
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Applications:
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FA
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Synonyms:
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AG-1343, AG1343, Viracept
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Formulation:
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Crystalline solid
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Chemical Name:
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(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide;methanesulfonic acid
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Molecular Formula:
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C32H45N3O4S CH3SO3H |
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Molecular Weight: |
663.9
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CAS Number
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159989-65-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Kaldor, S. W., Kalish, V. J., Davies, J. F., Shetty, B. V., Fritz, J. E., Appelt, K., ... & Dressman, B. A. (1997). Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. Journal of medicinal chemistry, 40(24), 3979-3985. Dube, M. P., Parker, R. A., Tebas, P., Grinspoon, S. K., Zackin, R. A., Robbins, G. K., ... & Snyder, S. W. (2005). Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides. Aids, 19(16), 1807-1818. Gills, J. J., LoPiccolo, J., & Dennis, P. A. (2008). Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy.Autophagy, 4(1), 107-109. |