Metformin hydrochloride
Catalog Number : 1117045
description
Metformin is an activator of the AMPK pathway and is reported to decrease hyperglycemia by the suppression of liver glucose production. Metformin improves insulin sensitivity and lower plasma glucose levels. It is reported to promote neurogenesis and exhibits an anti-proliferative effect in cancer lines.
Additional Information
Applications:
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FA
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Synonyms:
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Dimethylbiguanidine, Dimethylguanylguanidine, Glucophage, Metformin
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Formulation:
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Crystalline solid
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Chemical Name:
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3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
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Molecular Formula:
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C4H11N5 HCl |
Molecular Weight: |
165.6
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CAS Number
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1115-70-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Evans, J. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005). Metformin and reduced risk of cancer in diabetic patients. Bmj,330(7503), 1304-1305. Hirsch, H. A., Iliopoulos, D., & Struhl, K. (2013). Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proceedings of the National Academy of Sciences, 110(3), 972-977. Viollet, B., Guigas, B., Garcia, N. S., Leclerc, J., Foretz, M., & Andreelli, F. (2012). Cellular and molecular mechanisms of metformin: an overview.Clinical science, 122(6), 253-270. |