LGK974

Grouped product items
SizePrice Qty
1mg
$65.00
5mg
$180.00
Catalog Number : 1241454

description

LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity.
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Additional Information

Applications:
FA
Synonyms:
LGK-974, WNT-974, LGK 974
Formulation:
Crystalline solid
Chemical Name:
2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
Molecular Formula:

C23H20N6O

Molecular Weight:
396.4
CAS Number
1243244-14-5
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Liu, J., Pan, S., Hsieh, M. H., Ng, N., Sun, F., Wang, T., ... & Li, J. (2013). Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Proceedings of the National Academy of Sciences110(50), 20224-20229.

Glackin, C. A. (2014). Targeting the Twist and Wnt signaling pathways in metastatic breast cancer. Maturitas79(1), 48-51.

Pan, S., Cheng, D., Liu, J., Zhang, G., Hsieh, M. H., Ng, N., ... & Harris, J. L. (2014, August). Discovery of LGK974, a potent and selective Porcupine inhibitor targeting Wnt signaling. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 248). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.

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