LGK974
Catalog Number : 1241454
description
LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity.
Additional Information
Applications:
|
FA
|
Synonyms:
|
LGK-974, WNT-974, LGK 974
|
Formulation:
|
Crystalline solid
|
Chemical Name:
|
2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
|
Molecular Formula:
|
C23H20N6O |
Molecular Weight: |
396.4
|
CAS Number
|
1243244-14-5
|
Purity:
|
≥98%
|
Storage Conditions:
|
Product should be kept at -20°C.
|
References:
|
Liu, J., Pan, S., Hsieh, M. H., Ng, N., Sun, F., Wang, T., ... & Li, J. (2013). Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Proceedings of the National Academy of Sciences, 110(50), 20224-20229. Glackin, C. A. (2014). Targeting the Twist and Wnt signaling pathways in metastatic breast cancer. Maturitas, 79(1), 48-51. Pan, S., Cheng, D., Liu, J., Zhang, G., Hsieh, M. H., Ng, N., ... & Harris, J. L. (2014, August). Discovery of LGK974, a potent and selective Porcupine inhibitor targeting Wnt signaling. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 248). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC. |