LDN193189 Hydrochloride

Grouped product items
Size	Price	Qty
5mg	$90.00
25mg	$320.00

Catalog Number : 1066208

description

LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification. The salt-based form of LDN193189 has higher solubility in DMSO than LDN193189 (cat# 1062443).

Additional Information

Applications:	FA
Synonyms:	LDN-193189 hydrochloride, LDN193189 HCl
Formulation:	Crystalline solid
Chemical Name:	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;hydrochloride
Molecular Formula:	C₂₅H₂₂N₆ HCl
Molecular Weight:	443.0
CAS Number	1062368-62-0
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807 Kreitzer, F. R., Salomonis, N., Sheehan, A., Huang, M., Park, J. S., Spindler, M. J., ... & Conklin, B. R. (2013). A robust method to derive functional neural crest cells from human pluripotent stem cells. American journal of stem cells,2(2), 119. Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., ... & Paul, B. Y. (2012). Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 32(3), 613-622.