L-161,982
Catalog Number : 1470657
description
L-161,982 is a selective EP4 receptor antagonist that blocks PGE2-induced ERK phosphorylation and cell proliferation. It is reported to inhibit PGE2-induced bone formation in rats and the anti-inflammatory properties of PGE2 in human macrophages.
Additional Information
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Applications:
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FA
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Synonyms:
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L-161982, 147776-06-5, CHEMBL1395820
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Formulation:
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Crystalline solid
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Chemical Name:
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N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide
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Molecular Formula:
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C32H29F3N4O4S2 |
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Molecular Weight: |
654.2
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CAS Number
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147776-06-5
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Cherukuri, D. P., Chen, X. B., Goulet, A. C., Young, R. N., Han, Y., Heimark, R. L., ... & Nelson, M. A. (2007). The EP4 receptor antagonist, L-161,982, blocks prostaglandin E 2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Experimental cell research, 313(14), 2969-2979. Yanni, S. E., Barnett, J. M., Clark, M. L., & Penn, J. S. (2009). The role of PGE2 receptor EP4 in pathologic ocular angiogenesis. Investigative ophthalmology & visual science, 50(11), 5479. Aoudjit, L., Potapov, A., & Takano, T. (2006). Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor. American Journal of Physiology-Renal Physiology, 290(6), F1534-F1542. |