L-161,982
Catalog Number : 1470657
description
L-161,982 is a selective EP4 receptor antagonist that blocks PGE2-induced ERK phosphorylation and cell proliferation. It is reported to inhibit PGE2-induced bone formation in rats and the anti-inflammatory properties of PGE2 in human macrophages.
Additional Information
Applications: | FA |
Synonyms: | L-161982, 147776-06-5, CHEMBL1395820 |
Formulation: | Crystalline solid |
Chemical Name: | N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide |
Molecular Formula: | C32H29F3N4O4S2 |
Molecular Weight: | 654.2 |
CAS Number | 147776-06-5 |
Purity: | ≥95% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Cherukuri, D. P., Chen, X. B., Goulet, A. C., Young, R. N., Han, Y., Heimark, R. L., ... & Nelson, M. A. (2007). The EP4 receptor antagonist, L-161,982, blocks prostaglandin E 2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Experimental cell research, 313(14), 2969-2979. Yanni, S. E., Barnett, J. M., Clark, M. L., & Penn, J. S. (2009). The role of PGE2 receptor EP4 in pathologic ocular angiogenesis. Investigative ophthalmology & visual science, 50(11), 5479. Aoudjit, L., Potapov, A., & Takano, T. (2006). Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor. American Journal of Physiology-Renal Physiology, 290(6), F1534-F1542. |