JNJ-10198409

Grouped product items
SizePrice Qty
5mg
$105.00
50mg
$810.00
Catalog Number : 6274058

description

JNJ-10198409 is a potent Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) inhibitor that functions through its interaction with the ATP binding site. It is reported to exhibit antiangiogenetic and tumor antiproliferative properties.
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Additional Information

Applications:
FA
Synonyms:
JNJ 10198409, RWJ-540973
Formulation:
Crystalline solid
Chemical Name:
N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Molecular Formula:

C18H16FN3O2

Molecular Weight:
325.3
CAS Number
627518-40-5
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Zhang, L., Ma, J., Shen, T., Wang, S., Ma, C., Liu, Y., ... & Zhu, D. (2012). Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition. Cellular signalling24(10), 1931-1939.

Battegay, E. J., Rupp, J., Iruela-Arispe, L., Sage, E. H., & Pech, M. (1994). PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. The Journal of cell biology125(4), 917-928.

Ho, C. Y., Ludovici, D. W., Maharoof, U. S., Mei, J., Sechler, J. L., Tuman, R. W., ... & Li, J. (2005). (6, 7-Dimethoxy-2, 4-dihydroindeno [1, 2-c] pyrazol-3-yl) phenylamines: Platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. Journal of medicinal chemistry48(26), 8163-8173.

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