JAK Inhibitor I

Grouped product items
SizePrice Qty
1mg
$155.00
5mg
$345.00
Catalog Number : 4570371

description

JAK Inhibitor I is a potent and reversible Janus protein tyrosine kinases (JAKs) inhibitor that functions through its interaction with the ATP binding site. It is reported to inhibit the IL-2 and IL-4 dependent proliferation of CTLL cells and to block the phosphorylation of STAT5.
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Additional Information

Applications:
FA
Synonyms:
Pyridone 6, CMP-6, CMP 6
Formulation:
Crystalline solid
Chemical Name:
2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one
Molecular Formula:

C18H16FN3O

Molecular Weight:
309.3
CAS Number
457081-03-7
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Efe, J. A., Hilcove, S., Kim, J., Zhou, H., Ouyang, K., Wang, G., ... & Ding, S. (2011). Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nature cell biology13(3), 215.

Kim, J., Efe, J. A., Zhu, S., Talantova, M., Yuan, X., Wang, S., ... & Ding, S. (2011). Direct reprogramming of mouse fibroblasts to neural progenitors. Proceedings of the National Academy of Sciences108(19), 7838-7843.

Pedranzini, L., Dechow, T., Berishaj, M., Comenzo, R., Zhou, P., Azare, J., ... & Bromberg, J. (2006). Pyridone 6, a pan-Janus–activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer research66(19), 9714-9721.

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