Imatinib Mesylate

Grouped product items
Size Price Qty
25mg
$35.00
100mg
$95.00
Catalog Number : 2205712

description

Imatinib is a 2-phenyl animo pyrimidine derivate and tyrosine-kinase inhibitor that is used in the treatment of a variety of cancers. It binds close to the ATP binding site of Bcr-Abl, inhibiting its activity. It is also reported to be used to inhibit stem cell proliferation and erythropoiesis.

Additional Information

Applications:
FA
Synonyms:
Gleevec, Glivec, imatinib, imatinib methanesulfonate, STI571, STI-571
Formulation:
Crystalline solid
Chemical Name:
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Molecular Formula:

C29H31N7O CH4SO3

Molecular Weight:
589.7
CAS Number
220127-57-1
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., ... & Joensuu, H. (2002). Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. New England Journal of Medicine347(7), 472-480.

Talpaz, M., Silver, R. T., Druker, B. J., Goldman, J. M., Gambacorti-Passerini, C., Guilhot, F., ... & Sawyers, C. L. (2002). Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood99(6), 1928-1937.

Gal, H., Pandi, G., Kanner, A. A., Ram, Z., Lithwick-Yanai, G., Amariglio, N., ... & Givol, D. (2008). MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochemical and biophysical research communications376(1), 86-90.

O'Sullivan, S., Naot, D., Callon, K., Porteous, F., Horne, A., Wattie, D., ... & Grey, A. (2007). Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell‐dependent mechanisms. Journal of Bone and Mineral Research22(11), 1679-1689.

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