Hydroxychloroquine sulfate
Catalog Number : 7473646
description
Hydroxychloroquine sulfate is a synthetic quinolyl derivative that is commonly used as an antimalarial agent. It is reported to increase lysosomal pH in antigen presenting cells, inhibit autophagy and block toll-like receptors on plasmacytoid dendritic cells (PDCs). Hydroxychloroquine sulfate reduces the activation of dendritic cells and the inflammatory process. It is currently being researched as a potential treatment for COVID-19.
Additional Information
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Applications:
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FA
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Synonyms:
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Hydroxychlorochin, Oxychloroquine, Plaquenil, HCQ sulfate
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Formulation:
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Crystalline solid
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Chemical Name:
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2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid
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Molecular Formula:
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C18H26ClN3O H2SO4 |
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Molecular Weight: |
434.0
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CAS Number
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747-36-4
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Purity:
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95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Ben-Zvi, I., Kivity, S., Langevitz, P., & Shoenfeld, Y. (2012). Hydroxychloroquine: from malaria to autoimmunity. Clinical reviews in allergy & immunology, 42(2), 145-153. Gao, J., Tian, Z., & Yang, X. (2020). Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. BioScience Trends. Torigoe, M., Sakata, K., Ishii, A., Iwata, S., Nakayamada, S., & Tanaka, Y. (2018). Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition. Clinical Immunology, 195, 1-7. |